BAGH Projects
CGPH Projects:
Family Planning and Reproductive Health, Maternal Health, Child Health and Nutrition, Water and Sanitation, Health Workforce and Health Systems, Environmental Health, Neglected Tropical Diseases, Mental Health
CEND Projects:
Global Epidemics: HIV/AIDS, Tuberculosis, Malaria, Diarrheal Diseases
Discovery for Neglected Diseases: Parasitic Diseases, Viral Diseases, Bacterial Diseases, Pathogen Genomics
Tools for Control: Vaccines, Diagnostics, Therapeutics, Infectious Disease Modelling, Intellectual Property & Economic Policy
Family Planning and Reproductive Health
William Dow
• (Tanzania) Randomized HIV/STI prevention trial
• (Tanzania) Conditional cash transfers
Brenda Eskenazi, Steve Rappaport, Luoping Zhang
• (China: Tianjin)
Benzene and sperm
Suneeta Krishnan
• (India: Bangalore)
HIV, STI’s
Epidemiological study
Suellen Miller
• (Afghanistan: Kabul and peri urban areas)
Reproductive Health outcomes and contraceptive practices among women having “near miss” maternal morbidity
Nancy Padian
• (Zimbabwe) Urban and peri-urban
HIV; STIs; Effectiveness of diaphragms, plus male condoms; Unintended pregnancy; Vocational training
Art Reingold, Purnima Madhivanan
• (India: Mysore)
Rural
Effectiveness of traditional birth attendants
Lia Fernald
• (Magadascar) Community-based nutrition intervention for moms of young children
Paul Gertler
• (Argentina) Evaluation of provider pay for performance in maternal and child health care and health outcomes
Paul Gertler, Stef Bertozzi
• (Rwanda) Evaluation provider pay-for-performance in maternal and child health care, malaria prevention and treatment, and HIV/AIDS prevention and treatment
Suellen Miller
• (Afghanistan: Kabul and peri urban areas) Reproductive Health outcomes and contraceptive practices among women having “near miss” maternal morbidity
• (Egypt) Urban teaching hospitals
Quasi-experimental study of non-pneumatic shock garment (NASG) vs. standard treatment for hypovolemic shock secondary to obstetric hemorrhage
• (India: Maharashtra, Rajasthan, Tamil Nadu, Hyderabad, Ahmedabad)
Implementation of the Continuum of Care for PPH, prevention of PPH, early detection, communication and transportation, use of anti-shock garment for shock, and early appropriate treatment at facilities
• (Nigeria: 8 States)
Implementation of the Continuum of Care for PPH, prevention of PPH, early detection, communication and transportation, use of anti-shock garment for shock, and early appropriate treatment at facilities.
• (Zambia, Zimbabwe: Urban and peri-urban) Randomized cluster trial of early application of NASG vs. standard treatment of hypovolemic shock secondary to obstetric hemorrhage.
Ndola Prata
• (Bangladesh, Ethiopia, Nigeria)
Rural, community distribution of misoprostol for prevention of PPH
Safety and feasibility of community-base provision of DMPA (injectable contraceptive)
• (Tanzania) Rural, community distribution of misoprostol for treatment of PPH
Safety, feasibility, and effectiveness of misoprostol distribution through antenatal care visits
Colette (Coco) Auerswald
• (Kenya: Kisumu) Street children and youth in urban Western Kenya
Kisumu Street Children: A Pilot Study of STIs and HIV in Social Context
Mixed epidemiological and qualitative study of HIV and STIs in street children/youth
Brenda Eskenazi
• (Costa Rica)
Pesticides in children
Brenda Eskenazi, Asa Bradman, Lisa Goldman
• (Mexico: Michoacan, Guanajuato, Jalisco) PBDE, DDT in children
Brenda Eskenazi, Lisa Goldman, Lynnette Neufeld
• (Mexico: Michoacan, Guanajuato, Jalisco) Childhood Obesity
Brenda Eskenazi, Nina Holland
• (Mexico) Migration, pesticidas and obesity
Lia Fernald
• (Mexico) Growth trajectories, obesity, micro-nutrient supplementation
• (Ecuador) Conditional cash transfer program and child health outcomes
• (Magadascar) Community-based nutrition intervention for mothers of young children in impoverished, rural areas
Paul Gertler
• (Argentina)
Evaluation of provider pay for performance in maternal and child health care and health outcomes
Paul Gertler, Stef Bertozzi
• (Rwanda) Evaluation provider pay-for-performance in maternal and child health care, malaria prevention and treatment, and HIV/AIDS prevention and treatment
Paul Gertler & Lia Fernald
• (Mexico)
Cognitive stimulation interventions on child health and development
Paul Gertler, Lia Fernald, Stef Bertozzi
• (Mexico) Randomized conditional cash transfer program on child and adult health
Rita Hamad, Lia Fernald, Ndola Prata
• (Peru) Impact of microcredit intervention on child health
Kirk R. Smith, John Balmes, Nina Holland
• (Guatemala: Rural, highland, indigenous communities)
Childhood respiratory health, growth of lung function; chronic obstructive pulmonary disease in adult women, heart disease indicators, biomarkers of genetic susceptibility and oxidative stress, development and testing of innovative pollution monitoring and time-activity assessment technologies, interaction of spatial factors with disease and exposure, temperature as a risk factor for disease--Intervention (randomized): improved stove with chimney in wood-burning households
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Lee Riley
• (Brazil: Salvador)
Leptospirosis: risk factors
Interventions being examined: new diagnostic test for early interventions, Rheumatic Heart Disease
• (Brazil: Sao Paulo) Incidence of TB among close contacts--Intervention: diagnostic test to predict those at high risk progressing to TB
• (Brazil: Rio de Janeiro) Drug Resistant Infections, TB
Health Workforce and Health Systems
William Dow
• (Costa Rica)
National
Mortality, disability, allostatic load
Life-course behaviors
Paul Gertler
• (India)
Randomized health insurance trial
• (Argentina)
Evaluation of provider pay for performance in maternal and child health care and health outcomes
Paul Gertler, Stef Bertozzi
• (Rwanda) Evaluation provider pay-for-performance in maternal and child health care, malaria prevention and treatment, and HIV/AIDS prevention and treatment
Paul Gertler, Stef Bertozzi, Nancy Padian
• (Dominican Republic) Evaluation of impact of randomized job training and life skills training on risk behaviors.
Paul Gertler, Lia Fernald, Stef Bertozzi
• (Mexico) Randomized conditional cash transfer program on child and adult health
Eva Harris
• (Nicaragua: Managua)
Acute febrile illness; dengue; influenza-like illness; prospective cohort, hospital-based and community-based studies--Interventions: moving towards vaccine trials of tetravalent dengue vaccine; implementation of information technologies in Ministry of Health for improved vaccination efficiency and pre-natal care; evidence-based, community-derived interventions for mosquito control for prevention of dengue
Brenda Eskenazi
• (South Africa) Malaria and DDT applications: health effects; Limpopo
DDT and neurodevelopment
Kirk R. Smith
• (China)Validation and assessment of rural energy technologies for co-benefits, i.e., reductions in greenhouse emissions and improvements in health with a focus on women and young children
Intervention: Advanced low emissions household energy technologies
• (Uganda)Measurement of co-benefits of large-scale household energy intervention – greenhouse pollutant reductions and improved health in women and children.
Interventions: Improved wood and charcoal stoves.
Kirk R. Smith, Michael Bates
• (India: Chandigarh, Chennai)
TB and air pollution; development of innovative IT-based exposure and time-activity assessment technologies
• (Nepal) TB, cataracts, lens opacity as a biomarker of long-term exposure to air pollution
Kirk R. Smith, John Balmes, Nina Holland
• (Guatemala: Rural, highland, indigenous communities) Childhood respiratory health, growth of lung function; chronic obstructive pulmonary disease in adult women, heart disease indicators, biomarkers of genetic susceptibility and oxidative stress, development and testing of innovative pollution monitoring and time-activity assessment technologies, interaction of spatial factors with disease and exposure, temperature as a risk factor for disease--Intervention (randomized): improved stove with chimney in wood-burning households
Martyn Smith
• (China: Beijing and Guangzhou) Chemicals in the workplace
Grant Dorsey, Art Reingold
• (Uganda) Malaria surveillance
Paul Gertler, Stef Bertozzi
• (Rwanda) Evaluation provider pay-for-performance in maternal and child health care, malaria prevention and treatment, and HIV/AIDS prevention and treatment
Eva Harris
• (Nicaragua: Managua)
Urban, mostly poor; Acute febrile illness; dengue; influenza-like illness; prospective cohort, hospital-based and community-based studies--Interventions: moving towards vaccine trials of tetravalent dengue vaccine; implementation of information technologies in Ministry of Health for improved vaccination efficiency and pre-natal care; evidence-based, community-derived interventions for mosquito control for prevention of dengue
Lee Riley
• Brazil (Salvador)
Urban, favela (shantytown)
Leptospirosis: risk factors--Interventions being examined: new diagnostic test for early interventions, Rheumatic Heart Disease
Lia Fernald
• (South Africa) Microcredit intervention and psychological health
Lia Fernald, Paul Gertler
• (Mexico) Rural and urban poor
Stress and mental health outcomes
Gregory Barton, Professor, Molecular and Cell Biology
• Retroviral delivery of small interfering RNA into primary cells
Art Reingold, Professor, Epidemiology
• Opportunistic infections in AIDS patients
• Interrelationship between tuberculosis and AIDS in developing countries
David Schaffer, Professor, Chemical Engineering
• Molecular mechanisms of HIV-1 latency
• Optimizing therapies to suppress HIV: novel mechanisms of viral escape
Qiang Zhou, Professor, Molecular and Cell Biology
• The role of transcriptional elongation in HIV replication
Wayne Getz, Professor, College of Natural Resources, Department of Environmental Science, Policy and Management
• Analysis and modeling of the HIV epidemic in South Africa
• Forecasting HIV Evolution
Nancy Padian, Professor, Epidemiology
• Developing and evaluating female-controlled methods for HIV prevention
• Reducing women’s susceptibility to HIV/AIDS by building economic independence
Tuberculosis
Tom Alber, Professor, Molecular and Cel Biology, Lawrence Berkeley National Laboratory
• Ser/Thr/Tyr protein phosphorylation in Mycobacterium tuberculosis
James Berger, Professor, Molecular and Cell Biology
• Nucleic acid metabolism in Mycobacterium tuberculosis
Carolyn Bertozzi, Professor, Chemistry
• Mycobacterial sulfation pathways
Lee Riley, Professor, Epidemiology, Infectious Disease
• Pathogenesis of mycobacterial and enteric pathogens
• Molecular epidemiology of tuberculosis and drug-resistant gram-negative bacterial infections
Wayne Getz, Professor, College of Natural Resources, Department of Environmental Science, Policy and Management
• The spread of bovine tuberculosis in the African Buffalo in Kruger National Park
Jay Keasling, Professor, Chemical Engineering, Bioengineering, Lawrence Berkeley National Laboratory
• Biologically synthesized artemisinin to treat malaria
Kimmen Sjolander, Professor, Bioengineering
• Phylogenomic analysis of Plasmodium falciparum and related species
Michael Marletta, Professor, Chemistry
• Heme detoxification in Plasmodium falciparum
Jonathan Ellman, Professor, Chemistry
• Inhibitors of plasmepsin II for malaria treatment
• Potent 4-aminopiperidine based antimalarial agents
Zach Cande, Professor, Molecular and Cell Biology
• Investigating the function of kinesins in pathogenesis, flagellar assembly, and mitosis in Giardia
• Evolution of the actin cytoskeleton in Giardia
Daniel Fletcher, Professor, Bioengineering
• Understanding the method of attachment in the parasitic protozoan Giardia lamblia (in collaboration with professor Zach Cande)
Sangwei Lu, Professor, Infectious Diseases
• Pathogenesis and transmission of Salmonella
• Foodborne pathogens
• Foodborne diseases – detection and prevention
Jack Colford, Professor, Epidemiology
• Epidemiology and control of waterborne infectious diseases
Discovery for Neglected Diseases
Matthew Welch, Professor, Molecular and Cell Biology
• Developing drugs that target the cytoskeleton of trypanosomes
Peng Gong, Professor, Environmental Science, Policy, and Management
• The use of remote sensing for predictive modeling of schistosomiasis in China
Robert Spear, Professor, School of Public Health
• Schistosomiasis in China
• A spatial-temporal model for assessing the effects of intervillage connectivity in Schistosomiasis transmission
• Environmental effects on parasitic disease transmission exemplified by schistosomiasis in western China
Kara Nelson, Professor, Civil and Environmental Engineering
• Understanding light-mediated inactivation of pathogens in surface waters
• Tertiary filtration of wastewater for agricultural reuse
• Inactivation of Ascaris eggs by temperature, pH, and ammonia
• Pathogen detection using quantitative PCR
• Low-cost technologies for disinfection of drinking water at the point-of-use
Ellen Robey, Professor, Molecular and Cell Biology
• Immune responses to the intracellular parasite, Toxoplasma gondii
• Real-time imaging of T cell development
Zach Cande, Professor, Molecular and Cell Biology
• Investigating the function of kinesins in pathogenesis, flagellar assembly, and mitosis in Giardia
• Evolution of the actin cytoskeleton in Giardia
Bill Sha, Professor, Molecular and Cell Biology
• Control of B7h shedding by Toll-like receptors (TLRs)
• Is control of B7h expression a B cell-extrinsic mechanism involved in autoimmunity?
• Functional retroviral screens for host defense genes
Eva Harris, Professor, Infectious Disease
• Role of cis and trans factors in dengue virus translation
• Dengue reporter virus neutralization assay for clinical studies
• Antibody protection and enhancement of dengue virus in vivo
• Prospective cohort study of dengue transmission in Nicaragua
• Comparative genomics of dengue virus
• Assessment of existing dengue guidelines and evaluation of improved dengue clinical guidelines in Nicaragua
• Development of the dengue IDEA program
• Self-contained Electromagnetic Dengue Diagnostic Assay
• Nicaraguan Influenza Cohort Study
Jennifer Doudna, Professor, Molecular and Cell Biology
• Internal Ribosome Entry Site (IRES) RNAs in Hepatitis C virus
• RNA Recognition by Dicer Enzymes
Britt Glaunsinger, Professor, Plant and Microbial Biology
• Mechanisms by which herpesviruses promote global decay of cellular mRNAs during lytic infection
• What cellular pathways and proteins are required to promote global cellular mRNA destruction by γ-herpesviruses?
• What is the role of host shutoff in the viral lifecycle?
• How do viral transcripts selectively evade turnover?
Fenyong Liu, Professor, School of Public Health
• Studies of Nucleic Acid-based Agents for Inhibition of Viral Replication
Nilabh Shastri, Professor, Molecular and Cell Biology
• Molecular mechanisms that uniquely define cancer cells, microbial pathogens, and transplanted tissues as targets for the immune system
Qing Zhong, Professor, Molecular and Cell Biology
• Biochemical dissection of Autophagy pathway
• Autophagic responses to oncogenic stress, environmental toxicants exposure, and energy crisis.
Laurent Coscoy, Professor, Molecular and Cell Biology
• Immune Evasion by Herpesviruses
• Initial Events leading to Herpesvirus Persistence in Mouse Models
Michael Botchan, Professor, Molecular and Cell Biology
• Structure of the papillomavirus DNA-tethering complex E2:Brd4 and a peptide that ablates HPV chromosomal association
Art Reingold, Professor, Epidemiology
• Hepatitis B and C and Syphilis vulnerability related infections among institutionalized disadvantaged youth in São Paulo, Brazil
Lee Riley, Professor, Epidemiology, Infectious Disease
• Mechanism of persistent infection with Mycobacterium tuberculosis, agent of TB
• Molecular epidemiology of drug-resistant Gram-negative bacterial infections
Hiroshi Nikaido, Professor, Biochemistry, Molecular Biology
• Efflux-based drug resistance in bacteria
• Molecular basis of bacterial outer membrane permeability
Dan Portnoy, Professor, Molecular and Cell Biology
• Listeria monocytogenes as a model for intracellular bacterial pathogens
Russell Vance, Professor, Molecular and Cell Biology
• Role of Naip5 in immune defense against intracellular bacteria
• Cytosolic detection of bacterial flagellin by macrophages
• Novel cytosolic surveillance pathways for sensing infection
Richard Stephens, Professor, Molecular Epidemiology
• Molecular interactions of Chlamydia and the host in the context of specific microbe-cell interaction
• The genetic basis of chlamydial developmental regulation at the level of macromolecular chromosomal
• Molecular epidemiology of chlamydial infections
Suzanne Fleiszig, Professor, Vision Science and Optometry, Infectious Diseases & Immunity, Microbiology
• Pathogenesis of bacterial infections of the cornea
Sangwei Lu, Professor, Infectious Diseases
• Pathogenesis and transmission of Salmonella
• Foodborne pathogens
• Foodborne diseases – detection and prevention
Qing Zhong, Professor, Molecular and Cell Biology
• Biochemical dissection of Autophagy pathway
• Autophagic responses to oncogenic stress, environmental toxicants exposure, and energy crisis.
Brian Krantz, Professor, Molecular and Cell Biology, Chemistry
• Protein translocation across membranes
• Anthrax toxin translocation
Manfred Auer, Lawrence Berkeley National Laboratory, Bioenergy, Structural Biology
• Molecular mechanisms in cancer malignancy and metastasis with a focus on cell-cell adhesion patterns
• Study of the molecular composition and role of vesicles in Myxococcus xanthus
• Ultrastructural analysis of Myxococcus xanthus biofilms
• Ultrastructural characterization of S1/T4 cell lines in Matrigel
Kimmen Sjolander, Professor, Bioengineering
• Phylogenomic analysis of protozoa
• Innate immunity Phylogenomic Explorer
• Comparative genomics of human pathogens and parasites
Steve Brenner, Professor, Plant and Microbial Biology
• Medical and environmental metagenomics; personal genomics
Adam Arkin, Professor, Bioengineering, Chemistry
• E. coli metabolism, pili phase variation, transcriptional regulation, and phage infection
• Saccharomyces cerivisiae response to pharmaceuticals
• G-protein coupled signal transduction in cardiomyocytes and B-Cells
Montgomery Slatkin, Professor, Integrative Biology
• Modeling the genetic response to infectious diseases
• Population genetics of human genetic diseases, including linkage disequilibrium mapping, estimation of allele age, testing for natural selection, and modeling founder effects
Eva Harris, Professor, Infectious Disease
• Antibody protection and enhancement of dengue virus in vivo
• Dengue reporter virus neutralization assay for clinical studies
Russell Vance, Professor, Molecular and Cell Biology
• Using ENU mutagenesis to identify novel host genes essential for resistance to various intracellular pathogens
Dan Portnoy, Professor, Molecular and Cell Biology
• Understanding innate and acquired cell-mediated immunity using murine listeriosis
Lee Riley, Professor, Epidemiology and Infectious Disease
• Mechanism of persistent infection with Mycobacterium tuberculosis, agent of TB
• Molecular epidemiology of drug-resistant Gram-negative bacterial infections
Rich Mathies, Dean, College of Chemistry
• Integrated cell capture-PCR-capillary electrophoresis micro-device as part of a portable pathogen detection system
Daniel Fletcher, Professor, Bioengineering
• Developing microjets for needle-free drug delivery
• Telemicroscopy for disease diagnosis
Kara Nelson, Professor, Civil and Environmental Engineering
• Pathogen detection using quantitative PCR
• Understanding light-mediated inactivation of pathogens in surface waters
• Inactivation of Ascaris eggs by temperature, pH, and ammonia
• Low-cost technologies for disinfection of drinking water at the point-of-use
Dorian Liepmann, Professor, Bioengineering
• Micro-syringes for more effective vaccine and drug delivery
Eva Harris, Professor, School of Public Health
• Self-contained Electromagnetic Dengue Diagnostic Assay
Carolyn Bertozzi, Professor, Chemistry, Molecular and Cell Biology, Lawrence Berkeley National Laboratory
• Sulfation pathways in Mycobacterim tuberculosis
Jay Keasling, Professor, Chemical Engineering, Bioengineering, Lawrence Berkeley National Laboratory
• Biologically synthesized artemisinin to treat malaria
• Biologically synthesized prostratin and DPP to treat HIV
Matthew Welch, Professor, Molecular and Cell Biology
• Interaction between pathogens and the host actin cytoskeleton
• Developing drugs that target the cytoskeleton of parasites (specifically, trypanosomes)
Tom Alber, Professor, Molecular and Cell Biology
• Regulatory Mechanisms in Mycobacterium Tuberculosis
Jonathan Ellman, Professor, Chemistry
• Rapid Determination of Protease Substrate Specificity
• Identification of Protease Inhibitors
• Substrate Activity Screening (SAS) Method for the Rapid Identification of Enzyme Inhibitors
Wayne Getz, Professor, College of Natural Resources, Department of Environmental Science, Policy and Management
• The ecology of an environmentally maintained episodic disease: anthrax in Etosha National Park, Nambia
• Analysis and modeling of the HIV epidemic in South Africa
Alan Hubbard, Professor, School of Public Health
• Assessing risk from respiratory infections
• Dynamic models of infectious disease
Robert Spear, Professor, School of Public Health
• Schistosomiasis in China: Environmental Change and Parasite Diffusion
• Schistosomiasis in China: Disease Reemergence
Intellectual Property & Economic Policy
Stephen Maurer, Professor, Goldman School of Public Policy, Berkeley Law School
• Finding a Niche for Open Source Drug Discovery.
• R&D incentives for drug development.
David Levine, Professor, Haas School of Business
•Does Trade Affect Child Health
Amy Kapczynski, Professor, Berkeley Law School
Berkeley Center for Law & Technology
• Addressing Global Health Inequities: An Open Licensing Approach for University Innovations
Carol Mimura, Assistant Vice Chancellor, IPIRA
Intellectual Property and Industrial Research Alliances (IPIRA)
Socially Responsible IP Management
Laurel Fletcher, Clinical Professor of Law
International Human Rights Law Clinic
Sri Lanka Access to HIV Medicines Project
Madhu Messenger, Executive Director, IGCL
The Institute for Global Challenges and the Law
Promoting the Rule of Law